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What is in the syringe.
Hyaluronic acid, MCLPE cross-linking, and why five lines share one chemistry. And why the manufacturing that matters is now in Asia. Written for the person injecting.
Hyaluronic acid, defined.
A linear polysaccharide found in the dermis, which holds up to a thousand times its own weight in water. Free, it is broken down by hyaluronidase within 24 to 48 hours. To work as a filler it has to be stabilised — that is what cross-linking is. Sofiderm starts from pharmaceutical-grade HA obtained by fermentation, of non-animal origin.
MCLPE cross-linking. In stages, purified at the end.
MCLPE (Multiphase Cross Linking & Purification Enhancement) binds the chains with BDDE across successive reactions, purifies the gel by dialysis and swelling, and then binds the gel particles to un-cross-linked HA. A more stable network, with less residual cross-linker, and a gel that combines mechanical strength with glide through the needle.
Cross-linking across several successive reactions, purification at the end, and a microgel bound to free HA: more stability, less residue, better glide. See the five-stage process
Same chemistry. Different cohesivity, needle and plane.
What the manufacturer adjusts between lines is the cohesivity of the gel: its resistance to deformation and its tendency to stay compact in the tissue. Less cohesive for the superficial dermis, where it has to spread without ridging; more cohesive for the subcutaneous plane, where it has to project volume. The needle follows.
Cohesivity and duration
Relative cohesivity, indicative. Duration per the manufacturer's specification; it varies with the area, the technique and the patient.
Needle by line
Outer diameter to scale. The higher the gauge, the finer the needle. Manufacturer's needles in the 1 and 2 ml boxes: 27G in the dermis, 25G in the subcutaneous plane, Deep with one of each. The 10 and 20 ml syringes come without needles.
Depth decides the product.
Choose the plane first, the line second. Different lines can be used in one session, one per plane. At depth, less gel and more cohesive; near the surface, more fluid and less volume. Each line's indications are those of its CE certificate, on the line's own page.
Why Asian brands.
Much of the innovation and production capacity in hyaluronic acid now sits in Asia: manufacturers with ISO 13485, class III CE marking and decades of batches. What they lack in Europe is what Orvida adds: a verified dossier, stock in Portugal, and a responsible party the doctor can call. The chemistry is the same one you already use; what changes is the price and who answers.
What we get asked.
What role does BDDE play in the gel?
It is the cross-linker used for more than twenty years in CE-marked HA fillers. It reacts with the HA chain and becomes part of the polymer; free cross-linker is removed during purification.
If the chemistry is the same, what distinguishes the five lines?
The gel's cohesivity and the needle. The difference lies in how much the gel resists deformation, which defines the plane where it works best.
Is it reversible?
Yes. Like any hyaluronic acid filler, it can be degraded with hyaluronidase, following the technique and the precautions in the instructions for use.
Which documents come with each line?
Data sheet, instructions for use, CE certificate and declaration of conformity. By email, for verified clinics.
How is it stored and transported?
Between 2 and 30 °C, protected from light, with no cold chain at any point of the journey. Do not freeze.
How do I report an adverse event?
By email to vigilance@orvida.eu, with the lot number and a description. We reply within one working day and forward to the manufacturer and to INFARMED or AEMPS when applicable.
Rheology, certificates and literature.
Registered clinics receive the full technical dossier: CE certificate, declaration of conformity, data sheets and IFU.
