Sofiderm Derm Sub-Skin 20ml, HA Dermal Filler Refine
CE
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Sofiderm Derm Sub-Skin 20ml

2ml Pre-filled Syringe
Professional use only

High-density cross-linked hyaluronic acid engineered for mid-to-deep dermal injection. Delivers natural-looking volumisation for nose shaping, lip augmentation, chin definition, and jawline contouring. Developed using proprietary MCLPE cross-linking technology for optimal gel cohesivity and predictable clinical performance.

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In stock · Ships 2–5 business days Cold-chain to your clinic Professional use only
CE 2460 CE 2460
ISO 13485 ISO 13485
ISO 9001:2015 ISO 9001

Clinical Description

Clinical-volume (20ml) subcutaneous pack for extensive bony-landmark volumisation and structural face work. Awarded Best Injectable Body Filler at the AMWC 2026 Aesthetic Medicine Awards in Monte Carlo.

Indications

  • Nose shaping and non-surgical rhinoplasty
  • Lip augmentation and volumisation
  • Chin definition and projection
  • Jawline contouring and sculpting
  • Deep wrinkle and fold correction (nasolabial, marionette lines)
  • Facial volumisation and contour restoration

How It Works

MCLPE cross-linked HA at 20 ± 3 mg/ml creates a cohesive gel matrix that integrates smoothly with surrounding tissue. The high molecular weight and dense cross-linking provide structural support while maintaining a natural feel and movement. The gel's rheological properties ensure even distribution and predictable lift.

Benefits

  • Predictable, reproducible clinical results
  • Natural feel with smooth integration into host tissue
  • Long-lasting effect: 12 to 18 months depending on treatment area and patient metabolism
  • Low swelling ratio for minimal post-procedure oedema
  • Pre-filled syringe for convenience and reduced contamination risk
ProductSofiderm Derm Sub-Skin 20ml
Volume2ml pre-filled syringe
HA Concentration20 ± 3 mg/ml
Cross-linking
Needle27G TW
ApplicationMid-to-deep dermis
IndicationsNose, lips, chin, jawline, deep wrinkles
Duration6–24 months
Storage2–25°C, protect from light
Shelf Life24 months
CertificationISO 9001:2015 · ISO 13485 · GDPR
ManufacturerHangzhou Techderm
20 ± 3 mg/ml
HA Concentration
6–24mo
Duration of Effect
MCLPE
Technology

MCLPE Cross-linking Technology

The proprietary Multi-phase Cross-Linked Polymer Encapsulation (MCLPE) process produces a homogeneous gel matrix with controlled particle size distribution. This results in a filler with optimal viscoelastic properties: high G' (elastic modulus) for effective lift and projection, balanced with sufficient viscosity for smooth injection through fine-gauge needles.

Clinical evaluations demonstrate consistent volumisation across treatment areas, with a favourable safety profile and high patient satisfaction ratings. The cross-linking density is calibrated to resist enzymatic degradation while maintaining biocompatibility, contributing to a sustained duration of effect.

All Sofiderm products are manufactured under an audited quality management system and carry CE marking (Directive 93/42/EEC, Notified Body DNV 2460, in transition to the EU MDR under Regulation (EU) 2023/607).

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